Abstract #4152

Microstructural alterations in projection and association fibers in neonatal hypoxia-ischemia

Zuozhen Cao¹, Xiaoxia Shen², Fusheng Gao³, Tingting Liu¹, Zhiyong Zhao¹, Hongxi Zhang³, Lizhong Du², Jiangyang Zhang⁴, Yi Zhang¹, Can Lai³, Xiaolu Ma², and Dan Wu¹

¹College of Biomedical Engineering & Instrument Science, Zhejiang University, HangZhou, China, ²Department of Neonatal Intensive Care Unit, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, ³Department of Radiology, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, ⁴Department of Radiology, New York University School of Medicine, New York, NY, United States

Synopsis

Diffusion MRI (dMRI) is known to be sensitive to hypoxic-ischemic encephalopathy (HIE) , however, the existing dMRI studies only used diffusion tensor metrics in a few selected brain regions and primarily focus on severe-to-moderate HIE. Here we investigated microstructural alterations using multi-shell dMRI across the whole-brain in severe, moderate, and mild HIE babies (n=5/13/13) in comparison with control neonates (n=11) with region-of-interest-based, tract-based, and fixel-based analysis. We found microstructural alternations in projection and association fibers, especially the inferior fronto-occipital fasciculus and inferior longitudinal fasciculus that are important for visual functions.

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