Microstructural alterations in projection and association fibers in neonatal hypoxia-ischemia
Zuozhen Cao1, Xiaoxia Shen2, Fusheng Gao3, Tingting Liu1, Zhiyong Zhao1, Hongxi Zhang3, Lizhong Du2, Jiangyang Zhang4, Yi Zhang1, Can Lai3, Xiaolu Ma2, and Dan Wu1
1College of Biomedical Engineering & Instrument Science, Zhejiang University, HangZhou, China, 2Department of Neonatal Intensive Care Unit, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, 3Department of Radiology, Children's Hospital affiliated to Zhejiang University School of Medicine, HangZhou, China, 4Department of Radiology, New York University School of Medicine, New York, NY, United States
Diffusion MRI (dMRI) is known to be sensitive to hypoxic-ischemic encephalopathy (HIE) , however, the existing dMRI studies only used diffusion tensor metrics in a few selected brain regions and primarily focus on severe-to-moderate HIE. Here we investigated microstructural alterations using multi-shell dMRI across the whole-brain in severe, moderate, and mild HIE babies (n=5/13/13) in comparison with control neonates (n=11) with region-of-interest-based, tract-based, and fixel-based analysis. We found microstructural alternations in projection and association fibers, especially the inferior fronto-occipital fasciculus and inferior longitudinal fasciculus that are important for visual functions.
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