The current report summarizes the morphological characteristics of middle cerebral artery quantified from MRA scans in a large sample of older Chinese population and shows that higher M1 radius is an independent predictor of white matter hyperintensities (WMH). Furthermore, as the pathological changes resulting in white matter lesions are heterogeneous, the current study suggest that the spatial distribution patterns of WMH could reflect the underpinning pathological mechanisms, though further studies are required.
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