Middle Cerebral Artery Morphologies Associated with White Matter Hyperintensities
Boyu Zhang1, Zidong Yang1, Bei Wang1, Yajing Huo2, Huihui Lv2, Zhensen Chen1, Yan Han2, and He Wang1,3
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China, 3Human Phenome Institute, Fudan University, Shanghai, China
The current report summarizes the morphological characteristics of middle cerebral artery quantified from MRA scans in a large sample of older Chinese population and shows that higher M1 radius is an independent predictor of white matter hyperintensities (WMH). Furthermore, as the pathological changes resulting in white matter lesions are heterogeneous, the current study suggest that the spatial distribution patterns of WMH could reflect the underpinning pathological mechanisms, though further studies are required.
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