Abstract #4151

Middle Cerebral Artery Morphologies Associated with White Matter Hyperintensities

Boyu Zhang¹, Zidong Yang¹, Bei Wang¹, Yajing Huo², Huihui Lv², Zhensen Chen¹, Yan Han², and He Wang^1,3

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China, ³Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

The current report summarizes the morphological characteristics of middle cerebral artery quantified from MRA scans in a large sample of older Chinese population and shows that higher M1 radius is an independent predictor of white matter hyperintensities (WMH). Furthermore, as the pathological changes resulting in white matter lesions are heterogeneous, the current study suggest that the spatial distribution patterns of WMH could reflect the underpinning pathological mechanisms, though further studies are required.

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