Abstract #4156

Assessment of myocardial involvement in patients with Fabry disease using metabolic imaging by 1H-MR Spectroscopy (1H-MRS)

Masaru Shiotani¹, Yoshiaki Morita¹, Yoshito Ichiba², Yasuhiro Nagai¹, Wataru Ueki¹, Tatsuhiro Yamamoto¹, Yasutoshi Ohta¹, Keizo Murakawa¹, and Tetsuya Fukuda¹

¹Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, ²MR Research & CollaborationDpt. Diagnostic Imaging Division, Siemens Healthcare K.K., Shinagawa-ku, Tokyo, Japan

Synopsis

The peak ratio of 3.5ppm to water in 1H-MRS of myocardium showed the higher values in Fabry disease and the association with native T1 values and regional function. 1H-MRS has a potential as disease-specific imaging biomarker for direct quantification of myocardial sphingolipid accumulation of Fabry disease.

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