Abstract #4156
Assessment of myocardial involvement in patients with Fabry disease using metabolic imaging by 1H-MR Spectroscopy (1H-MRS)
Masaru Shiotani1, Yoshiaki Morita1, Yoshito Ichiba2, Yasuhiro Nagai1, Wataru Ueki1, Tatsuhiro Yamamoto1, Yasutoshi Ohta1, Keizo Murakawa1, and Tetsuya Fukuda1
1Department of Radiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, 2MR Research & CollaborationDpt. Diagnostic Imaging Division, Siemens Healthcare K.K., Shinagawa-ku, Tokyo, Japan
Synopsis
The peak ratio of 3.5ppm to water in 1H-MRS of myocardium showed the higher values in Fabry disease and the association with native T1 values and regional function. 1H-MRS has a potential as disease-specific imaging biomarker for direct quantification of myocardial sphingolipid accumulation of Fabry disease.
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