Hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) share similar features, such as thickened left ventricular (LV) wall and reduced compliance, which make it difficult to distinguish HCM from HHD clinically. In this retrospective study, patients with HCM and HHD were enrolled to evaluate the feasibility of radiomic analysis to differentiate between these two diseases. For all calculated texture analysis (TA) features, AUCs of nine parameters had the values above 0.65, Logarithm_glszm_ZoneEntropy reached the best performance than other parameters (AUC: 0.790, sensitivity: 71.4 %, specificity: 81.8 %, P < 0.01).
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