Acute myocardial infarction is the result of occlusion of cardiac arteries, which leads to myocardial ischemic injury and even necrosis. Diffusion weighted imaging (DWI) and T2* mapping were performed to investigate the correlation between apparent diffusion coefficient (ADC) and T2* values in ST-segment elevation myocardial infarction (STEMI) patients here. ADC values of infarct regions were higher than those in border regions, remote regions in patients with STEMI, and also higher when compared with control group. Conversely, T2* values showed opposite trend. What’s more, there was a negative correlation between T2* and ADC values (r = 0.-734; P < .001).