Coronary heart disease is an urgent, rapidly-developing disease with high disability and mortality. Previous studies indicated that CHD patients exhibited an increased risk of mild cognitive and emotional dysfunction. Here we collected rs-fMRI data to assess global brain activity in CHD patients and controls by measuring fALFF. We demonstrated that CHD patients occur abnormal brain activity in left precentral/postcentral gyrus and right inferior cerebellum, which is mainly related to sensorimotor network and pain processing. Spontaneous brain activity abnormalities may contribute to understanding underlying neurological mechanisms of CHD.