Noninvasive Diagnosis of Portal Hypertension and Detecting High Risk Gastroesophageal Varices in Chronic Liver Disease Patients with 4D Flow MRI
Jiachen Ji1, Hanyu Wei1, Yunduo Li1, Mengmeng Zhang2, Changchun Liu2, Bo Jin3, Xiaolong Qi4, Wen Shen5, Jianming Cai2, and Rui Li1
1Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua Univ., Beijing, China, 2Radiology, Department of Radiology, The Fifth Medical Centre of Chinese PLA General Hospital, Beijing, China, 3First Liver Cirrhosis Diagnosis and Treatment Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China, 4CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China, 5Department of Radiology, First Center Hospital of Tianjin, Tianjin, China
Chronic liver disease patients commonly suffer from portal hypertension (PH), which could lead to gastroesophageal varices. Noninvasive methods to diagnose PH and to detect high risk varices are urgently needed. 4D Flow MRI is an advanced technique which could provide visualization and quantification of blood flow. In the study, we observed significant hemodynamic differences in portal vein between PH patients and controls. Similar differences were observed between patients with high risk and low risk varices. The performance of diagnosing PH/detecting high risk varices using the single hemodynamic parameter and the logistic regression model was acknowledged by the ROCs.
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