Abstract #4193

Noninvasive Diagnosis of Portal Hypertension and Detecting High Risk Gastroesophageal Varices in Chronic Liver Disease Patients with 4D Flow MRI

Jiachen Ji¹, Hanyu Wei¹, Yunduo Li¹, Mengmeng Zhang², Changchun Liu², Bo Jin³, Xiaolong Qi⁴, Wen Shen⁵, Jianming Cai², and Rui Li¹

¹Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua Univ., Beijing, China, ²Radiology, Department of Radiology, The Fifth Medical Centre of Chinese PLA General Hospital, Beijing, China, ³First Liver Cirrhosis Diagnosis and Treatment Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China, ⁴CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China, ⁵Department of Radiology, First Center Hospital of Tianjin, Tianjin, China

Synopsis

Chronic liver disease patients commonly suffer from portal hypertension (PH), which could lead to gastroesophageal varices. Noninvasive methods to diagnose PH and to detect high risk varices are urgently needed. 4D Flow MRI is an advanced technique which could provide visualization and quantification of blood flow. In the study, we observed significant hemodynamic differences in portal vein between PH patients and controls. Similar differences were observed between patients with high risk and low risk varices. The performance of diagnosing PH/detecting high risk varices using the single hemodynamic parameter and the logistic regression model was acknowledged by the ROCs.

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