Gd-EOB-DTPA-enhanced MRI was used to quantitatively assess liver function benefiting the follow-up of patients with chronic liver disease and the appropriate plan for liver cancer treatment. A systematic multi-parametric analysis with non-enhanced and Gd-EOB-DTPA-enhanced T1 weighted and T1 mapping MRI were conducted to assess the liver function in patients with cirrhosis. Independent factor for differentiation of A+N(normal and Child-Pugh A) and B+C (Child-Pugh B and C) were found to be RE_Liver, T1_Native, T1_Post and ΔT1_Liver, while for differentiation of Child-Pugh B and C were found to be ΔT1_Liver and SIR_Bdult/Muscle. Both combined model with these factors obtained better diagnostic performance.
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