Abstract #4191

NAFLD and Hepatic Inflammation: Multi-modal MR-Investigations of Disease Progression

Christian Simonsson^1,2,3, Markus Karlsson^2,3, Patrik Nasr^3,4, Ralph Sinkus ^5,6, Simone Ignatova⁷, Nils Dahlström^2,3, Mattias Ekstedt^3,4, Stergios Kechagias^3,4, and Peter Lundberg^2,3

¹Department of Biomedical Engineering (IMT), Linköping University, Linköping, Sweden, ²Department of Radiation Physics, Radiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ³Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁴Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁵Imaging Sciences & Biomedical Engineering, Kings College, London, United Kingdom, ⁶LVTS, INSERM U1148, Paris, France, ⁷Department of Clinical Pathology and Clinical Genetics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

Synopsis

Several MR-biomarkers characterizing different aspects of NAFLD progression, especially for the early onset, and late stages, are available. However, there is a need to combine and characterize, not only the endpoints but also the intermediate stages of the disease, in particular the early stages of hepatic inflammation. Using an extensive multi-modal MRI protocol, we have investigated correlations between different MR-biomarkers with histopathology measurements of hepatic inflammation, fat accumulation and fibrosis. The long-term aim of this research is to characterize each patient in the early to intermediate stages of disease progression, with a higher degree of precision.

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