DWI can indirectly reflect the changes of tissue microstructure by detecting the direction and extent of water molecule diffusion. In liver fibrosis, collagen fibers and cell membranes may block the diffusion of water molecules, resulting in changes in the diffusion signal. B-value selection is closely related to the image quality of DWI. Previous studies have found the correlation between tissue water diffusivity and tissue elasticity in the liver. However, there are no widely accepted ADC values on the b-value combination for the stiffness of liver fibrosis. Therefore, the study of b-value combination optimization is of important clinical interest.