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Abstract #4189

Assessment of fibrotic liver regeneration with IVIM imaging: an experimental study in a rat model

Shuangshuang Xie1, Caixin Qiu1, Yajie Sun1, Jinxia Zhu2, Robert Grimm3, and Wen Shen1
1Tianjin First Central Hospital, Tianjin, China, 2MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 3MR Application development, Siemens Healthcare GmbH, Erlangen, Germany


This study investigated the feasibility of IVIM to evaluate fibrotic liver regeneration and function recovery after partial hepatectomy in a rat model. In fibrotic rats, significant increase in D values and decrease in D* and PF values followed with recovery to pre-PH levels were shown. PF values correlated well with Ki-67 indices, D* and PF values correlated well with ALT, AST, and TBil values. IVIM may be an noninvasive and promising approach to monitor liver regeneration and functional recovery after PH.

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