Rectal mucinous adenocarcinoma (MC) is a typical subtype of rectal adenocarcinomas, which has a poor prognosis and it is not sensitive to neoadjuvant chemoradiotherapy thus associated with significantly different individualized treatments as those for rectal common adenocarcinoma (AC). The amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging were investigated in this study for differential diagnosis between MC and AC. Results indicated that APT signal intensity and the D value by IVIM can be used in discriminating between MC and AC, slightly inferior to the performance of apparent diffusion coefficient by conventional diffusion weighted imaging.
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