Abstract #4198

MR fingerprinting for liver tissue characterization in a single breath-hold scan: A histopathological correlation study

Shohei Fujita^1,2, Katsuhiro Sano¹, Gastao Cruz³, Yuki Fukumura⁴, Hideo Kawasaki¹, Issei Fukunaga¹, Masami Yoneyama⁵, Koji Kamagata¹, Osamu Abe², Kenichi Ikejima⁶, Rene Botnar³, Claudia Prieto³, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ⁴Department of Human Pathology, Juntendo University, Tokyo, Japan, ⁵MR Clinical Science, Philips Japan, Tokyo, Japan, ⁶Department of Gastroenterology, Juntendo University, Tokyo, Japan

Synopsis

Magnetic resonance fingerprinting (MRF) has been proposed for simultaneous T1, T2, T2*, and fat-fraction mapping of the liver, which is suitable for the diagnosis and monitoring of liver diseases. We evaluated the repeatability of liver MRF measurements and correlated it with reference standard imaging in patients with diffuse liver disease. Furthermore, we validated MRF-derived measurements against histological grading of liver biopsies. Liver MRF provided repeatable multi-parametric maps with high agreement with measurements of separate conventional quantitative mapping as well as histological grading of liver biopsies. This approach may enable objective and non-invasive hepatic tissue characterization in a single breath-hold scan.

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