MR fingerprinting for liver tissue characterization in a single breath-hold scan: A histopathological correlation study
Shohei Fujita1,2, Katsuhiro Sano1, Gastao Cruz3, Yuki Fukumura4, Hideo Kawasaki1, Issei Fukunaga1, Masami Yoneyama5, Koji Kamagata1, Osamu Abe2, Kenichi Ikejima6, Rene Botnar3, Claudia Prieto3, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 4Department of Human Pathology, Juntendo University, Tokyo, Japan, 5MR Clinical Science, Philips Japan, Tokyo, Japan, 6Department of Gastroenterology, Juntendo University, Tokyo, Japan
Magnetic resonance fingerprinting (MRF) has been proposed for simultaneous T1, T2, T2*, and fat-fraction mapping of the liver, which is suitable for the diagnosis and monitoring of liver diseases. We evaluated the repeatability of liver MRF measurements and correlated it with reference standard imaging in patients with diffuse liver disease. Furthermore, we validated MRF-derived measurements against histological grading of liver biopsies. Liver MRF provided repeatable multi-parametric maps with high agreement with measurements of separate conventional quantitative mapping as well as histological grading of liver biopsies. This approach may enable objective and non-invasive hepatic tissue characterization in a single breath-hold scan.
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