Magnetic resonance fingerprinting (MRF) has been proposed for simultaneous T1, T2, T2*, and fat-fraction mapping of the liver, which is suitable for the diagnosis and monitoring of liver diseases. We evaluated the repeatability of liver MRF measurements and correlated it with reference standard imaging in patients with diffuse liver disease. Furthermore, we validated MRF-derived measurements against histological grading of liver biopsies. Liver MRF provided repeatable multi-parametric maps with high agreement with measurements of separate conventional quantitative mapping as well as histological grading of liver biopsies. This approach may enable objective and non-invasive hepatic tissue characterization in a single breath-hold scan.
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