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Abstract #4243

T1 mapping with extracellular volume fraction measurement to evaluate histological features of cervical squamous cell carcinoma

Shujian Li1, Jie Liu1, Marcel Dominik Nickel2, Jingliang Cheng1, and Jinxia Zhu3
1the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Healthcare Ltd, Beijing, China


This study investigated the feasibility of extracellular volume fraction (ECV) measurement using T1 mapping to evaluate histological grade, lymphovascular space invasion (LVSI) status, perineural invasion (PNI) status, and Ki-67 proliferation index (PI) of cervical squamous cell carcinoma (CSCC), and to compare T1 mapping with diffusion-weighted imaging (DWI). Results showed that T1 mapping-derived parameters (ΔT1, ECV) can effectively grade and predict CSCC LVSI status, PNI status, and Ki-67 PI, and ADC values can stratify CSCC grading. ECV may represent an effective quantitative imaging biomarker indicating the poor-prognosis histological features of CSCC and may provide incremental diagnostic value beyond qualitative MRI features.

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