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Abstract #4250

Multifrequency MR elastography for the detection of Glypican 3-positive hepatocellular carcinoma

Yihuan Wang1, Ruokun Li1, Jiahao Zhou1, Jing Guo2, Ingolf Sack2, and Fuhua Yan1
1Department of Radiology, Department of Radiology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Department of Radiology, Charité–Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany


Glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC) is often associated with a poor prognosis. GPC3 is a promising target for tumor-specific immunotherapy in HCC. We investigated the diagnostic performance of viscoelastic properties quantified by tomoelastography, a multifrequency MR-elastography (MRE) technique, for the detection of GPC3-positive HCC. Preliminary results showed that reduced stiffness quantified by tomoelastography is a mechanical signature of positive GPC3 expression in HCC. Combining stiffness and serum alpha-fetoprotein (AFP) level could be considered as a viable biomarker for detecting GPC3-positive HCC as well as for predicting the outcome of GPC3-targeted immunotherapy.

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