Abstract #4257

Water specific T1 mapping for characterization of inflammation grades at early stage in Rats with Non-alcoholic fatty liver disease (NAFLD)

Qian Wan¹, Hao Peng ¹, Jianxun Lyu¹, Yi Wang², Feng Liu², Chuanli Cheng¹, Yangzi Qiao¹, Hairong Zheng¹, Xin Liu¹, and Chao Zou¹

¹Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Peking University People's Hospital, Beijing, China

Synopsis

Detection of inflammation is important to the NAFLD patients. Liver biopsy is limited by the sampling error. T1 quantification from MRI is believed to be one of promising imaging method to detect inflammation. However, intracellular hepatocyte lipid is a confounding factor for the accurate T1 quantitation in the case of the NAFLD. This study established a variable flip-angle multi-echo GRE sequence to produce the T1 value of water component (wT1) in a NAFLD rat model who underwent biopsy. The results indicate that wT1 could discriminate between moderate and severe inflammation stages (G2 +G3) from the no and mild stages (G0+G1).

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