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Abstract #4257

Water specific T1 mapping for characterization of inflammation grades at early stage in Rats with  Non-alcoholic fatty liver disease (NAFLD)

Qian Wan1, Hao Peng 1, Jianxun Lyu1, Yi Wang2, Feng Liu2, Chuanli Cheng1, Yangzi Qiao1, Hairong Zheng1, Xin Liu1, and Chao Zou1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Peking University People's Hospital, Beijing, China


Detection of inflammation is important to the NAFLD patients. Liver biopsy is limited by the sampling error. T1 quantification from MRI is believed to be one of promising imaging method to detect inflammation. However, intracellular hepatocyte lipid is a confounding factor for the accurate T1 quantitation in the case of the NAFLD. This study established a variable flip-angle multi-echo GRE sequence to produce the T1 value of water component (wT1) in a NAFLD rat model who underwent biopsy. The results indicate that wT1 could discriminate between moderate and severe inflammation stages (G2 +G3) from the no and mild stages (G0+G1).

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