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Abstract #4291

Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI During Radiotherapy in Patients with Head and Neck Cancer (PREDICT-HN study)

Sweet Ping Ng1, Carlos Cardenas2, Houda Bahig3, JiHong Wang4, Jason Johnson4, Ying Yuan4, Amy Moreno4, and Clifton Fuller4
1Austin Health, Heidelberg, Australia, 2University of Birmingham Alabama, Birmingham, AL, United States, 3Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, 4MD Anderson Cancer Center, Houston, TX, United States


We evaluated the weekly ADC kinetics of tumour during radiotherapy for head and neck cancer in the PREDICT-HN study. of 41 patients, 36 had intact primary tumours, and 31 patients had nodal disease with 46 nodes assessed. For primary tumours, a steep increase in ADC values from pre-treatment to week 2, and from weeks 5 to post-treatment was observed. For nodes, ADC values increased from pre-treatment to week 4, and then decreased thereafter. A discrepancy in the trajectory of ADC changes between primary and nodal sites suggesting that they exhibit different treatment responses.

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