We evaluated the weekly ADC kinetics of tumour during radiotherapy for head and neck cancer in the PREDICT-HN study. of 41 patients, 36 had intact primary tumours, and 31 patients had nodal disease with 46 nodes assessed. For primary tumours, a steep increase in ADC values from pre-treatment to week 2, and from weeks 5 to post-treatment was observed. For nodes, ADC values increased from pre-treatment to week 4, and then decreased thereafter. A discrepancy in the trajectory of ADC changes between primary and nodal sites suggesting that they exhibit different treatment responses.
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