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Abstract #4317

3D diffusion MRI with Twin-navigator-based GRASE for comparison of fiber-tracking using 2D and 3D sequences in human whole brain

Haotian Li1, Yi-Cheng Hsu2, Tao Zu1, Yi Sun2, Yi Zhang1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens Healthineers Ltd., Shanghai, China


3D pulse sequences enable high-resolution acquisition with high SNR and ideal slice profiles, which however, is particularly difficult for diffusion MRI (dMRI) due to the additional phase errors from diffusion encoding. Here we proposed a twin-navigator based 3D diffusion-weighted gradient spin-echo (DW-GRASE) sequence to correct the phase errors between shots for human whole-brain acquisition. Moreover, we tested whether acquisitions may impact the fiber-tracking results by comparing the 3D-GRASE with 2D-EPI using the fixel-based analysis, which indicated a significant difference between the 3D and 2D sequences in several microstructural parameters of the long cerebrospinal tract and splenium of corpus callous.

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