This study developed a molecularly targeted magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS) method to selectively probe a specific metabolite molecule of tissues/organs in vivo. Several biomolecules have been used for molecularly targeted MRI and MRS. We used N-acetyl aspartate (NAA)- and glutamate (GLU)-targeted 1H MRS spectra of the human brain and reported a novel approach to measure the local pH values of tissue in vivo.
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