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Abstract #4318

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy

Ye-Feng Yao1, Jia-Xiang Xin1, Guang Yang1, Huojun Zhang2, Jiaqi Li1, Caixia Fu3, Jiachen Wang1, Rui Tong1, and Daxiu Wei1
1Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 2Shanghai Changhai Hospital, Shanghai, China, 3Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China


This study developed a molecularly targeted magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS) method to selectively probe a specific metabolite molecule of tissues/organs in vivo. Several biomolecules have been used for molecularly targeted MRI and MRS. We used N-acetyl aspartate (NAA)- and glutamate (GLU)-targeted 1H MRS spectra of the human brain and reported a novel approach to measure the local pH values of tissue in vivo.

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