Abstract #4318

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy

Ye-Feng Yao¹, Jia-Xiang Xin¹, Guang Yang¹, Huojun Zhang², Jiaqi Li¹, Caixia Fu³, Jiachen Wang¹, Rui Tong¹, and Daxiu Wei¹

¹Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, ²Shanghai Changhai Hospital, Shanghai, China, ³Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Synopsis

This study developed a molecularly targeted magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS) method to selectively probe a specific metabolite molecule of tissues/organs in vivo. Several biomolecules have been used for molecularly targeted MRI and MRS. We used N-acetyl aspartate (NAA)- and glutamate (GLU)-targeted ¹H MRS spectra of the human brain and reported a novel approach to measure the local pH values of tissue in vivo.

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