Based on field-of-view optimized and constrained undistorted single shot (FOCUS) combined with multiplexed sensitivity-encoding (MUSE) techinique, a new diffusion-weighted imaging (DWI) sequence was developed in our study (named FOCUS MUSE-DWI). Our aim is to assess FOCUS MUSE-DWI’ reliability with comparison to single-shot DWI (ss-DWI), FOCUS-DWI and MUSE-DWI with the evaluation of apparent diffusion coefficient (ADC) repeatability, surrogate signal-to-noise ratio (sSNR) and image quality. FOCUS MUSE-DWI can provide sufficient sSNR and excellent image quality, best ADC repeatability in above four DWIs. It suggests that FOCUS MUSE-DWI is a reliability technique and should be recommended for the clinical application of pancrentic DWI.
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