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Abstract #4359

Assessment of Glx and GABA levels in the Global Developmental Disability Children: A Magnetic Resonance Spectroscopy Study

Zhuo Hang Liu1, Dan LI1, Liang Jie Lin2, Ke Jiang2, Shan Ling3, Fei Yong Jia3, Bing Yang Bian1, Zhuo Wang1, Dan Dan Guo1, and Ying Qiu1
1Radiology, the First Hospital of Jilin University, Changchun, China, 2Philips Healthcare, Beijing, China, Beijing, China, 3Departments of Developmental Behavioral Pediatrics, the First Hospital of Jilin University, Changchun, China


This study aims to explore the correlation between brain neuro metabolites and clinical symptom scales in GDD and GDD+ASD. 11 children with GDD and 12 GDD +ASD children took MR scans, and completed the GABA and Glx spectroscopic acquisition. Results indicated that there is a significant difference in DQ language levels between GDD and GDD+ASD, and the GABA/Cr levels were significantly decreased in GDD+ASD compared with GDD. A positive correlation was observed between Glx/Cr and ADOS stereotype among all participants, and a clear link was observed between Glx/Cr and the sensory symptoms of ASD at both behavioral and perceptual levels.

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