Abstract #4359

Assessment of Glx and GABA levels in the Global Developmental Disability Children: A Magnetic Resonance Spectroscopy Study

Zhuo Hang Liu¹, Dan LI¹, Liang Jie Lin², Ke Jiang², Shan Ling³, Fei Yong Jia³, Bing Yang Bian¹, Zhuo Wang¹, Dan Dan Guo¹, and Ying Qiu¹

¹Radiology, the First Hospital of Jilin University, Changchun, China, ²Philips Healthcare, Beijing, China, Beijing, China, ³Departments of Developmental Behavioral Pediatrics, the First Hospital of Jilin University, Changchun, China

Synopsis

This study aims to explore the correlation between brain neuro metabolites and clinical symptom scales in GDD and GDD+ASD. 11 children with GDD and 12 GDD +ASD children took MR scans, and completed the GABA and Glx spectroscopic acquisition. Results indicated that there is a significant difference in DQ language levels between GDD and GDD+ASD, and the GABA/Cr levels were significantly decreased in GDD+ASD compared with GDD. A positive correlation was observed between Glx/Cr and ADOS stereotype among all participants, and a clear link was observed between Glx/Cr and the sensory symptoms of ASD at both behavioral and perceptual levels.

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