Abstract #4360

Effect of GABA and Glx Levels on the Medication Overuse Headache

Xiaoyan Bai^1,2, Zhangxuan Hu³, Wei Wang⁴, Xueyan Zhang⁵, Zhiye Li¹, Yonggang Wang⁴, and Binbin Sui²

¹Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing, China, Beijing, China, ²Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China, ³GE Healthcare, Beijing, China, Beijing, China, ⁴Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Headache Center, China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China, ⁵Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Zhengzhou, China

Synopsis

Eight medication overuse headache (MOH) patients and eight healthy controls (HCs) were recruited to explore the potential neuroimage biomarkers based on ¹H-MRS. The Glx (glutamate and glutamine) and γ-aminobutyric acid (GABA) levels in thalamus and PAG regions were compared between MOH and HC groups. The MOH group had lower GABA+/water and higher Glx/Cr ratios than HC group in the PAG. Also,higher Glx/Cr and Glx/water ratios were found in the left thalamus with MOH group. These results might be better explaining the pathophysiology mechanism of MOH in the trigeminovascular pain pathways, and guiding the clinical targeted drug treatment for MOH patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.