Abstract #4360
Effect of GABA and Glx Levels on the Medication Overuse Headache
Xiaoyan Bai1,2, Zhangxuan Hu3, Wei Wang4, Xueyan Zhang5, Zhiye Li1, Yonggang Wang4, and Binbin Sui2
1Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing, China, Beijing, China, 2Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China, 3GE Healthcare, Beijing, China, Beijing, China, 4Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Headache Center, China National Clinical Research Center for Neurological Diseases, Beijing, China, Beijing, China, 5Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Zhengzhou, China
Synopsis
Eight medication overuse headache (MOH) patients and eight healthy controls (HCs) were recruited to explore the potential neuroimage biomarkers based on 1H-MRS. The Glx (glutamate and glutamine) and γ-aminobutyric acid (GABA) levels in thalamus and PAG regions were compared between MOH and HC groups. The MOH group had lower GABA+/water and higher Glx/Cr ratios than HC group in the PAG. Also,higher Glx/Cr and Glx/water ratios were found in the left thalamus with MOH group. These results might be better explaining the pathophysiology mechanism of MOH in the trigeminovascular pain pathways, and guiding the clinical targeted drug treatment for MOH patients.
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