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Abstract #4362

In-vivo measurement of hepatic unsaturated lipid using J-difference-edited MRS.

Dingyi Lin1, Yang Cao1, Yi-Cheng Hsu2, Hong Li3, Jiaqiang Zhou3, Fenping Zheng3, and Min Wang1
1College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens healthineers ltd., Shanghai, China, 3Department of Endocrine, Sir Run Run Shaw Hospital, Hangzhou, China


Measurement of lipid composition in liver is of high importance. The J-difference-edited MRS allows detection of low-level overlapped metabolites, including hepatic unsaturated lipid. This study was to investigate the efficacy of J-editing on human hepatic unsaturated lipid, with different experimental setup. Multiple potential influencing factors such as breath control and voxel localization were parallelly compared. In-vivo hepatic MRS data was acquired in three healthy subjects. The statistical analysis of experimental variance and test re-test reliability demonstrates that MEGA-PRESS with respiratory-gating at lower level in liver allows consistent and robust in-vivo measurement of different human hepatic unsaturated lipid molecules.

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