Measurement of lipid composition in liver is of high importance. The J-difference-edited MRS allows detection of low-level overlapped metabolites, including hepatic unsaturated lipid. This study was to investigate the efficacy of J-editing on human hepatic unsaturated lipid, with different experimental setup. Multiple potential influencing factors such as breath control and voxel localization were parallelly compared. In-vivo hepatic MRS data was acquired in three healthy subjects. The statistical analysis of experimental variance and test re-test reliability demonstrates that MEGA-PRESS with respiratory-gating at lower level in liver allows consistent and robust in-vivo measurement of different human hepatic unsaturated lipid molecules.
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