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Abstract #4366

Hyperpolarized 13C-pyruvate MR metabolic imaging in Aging 

Nguyen Trong Nguyen1, Onila N. M. D. Rasanjala2, Eun Hui Bae3, and Ilwoo Park2,4
1Department of Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, 2Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of, 3Department of Internal Medicine, Chonnam National University, Gwangju, Korea, Republic of, 4Department of Radiology, Chonnam National University, Gwangju, Korea, Republic of

Synopsis

Hyperpolarized [1-13C1]pyruvate MRI data were obtained in vivo metabolic data from young and aged animals in rodent to elucidate the different changes in metabolism due to aging. The preliminary results in this study demonstrated the feasibility of using hyperpolarized MRI 13C technique for identifying renal metabolic changes between aged and young animals. The reduction of Lac/Pyr, Ala/Pyr and BiC/Pyr ratio may be used as biomarkers for the cellular dysfunction that accompanies the aging process. The results from this study warrant further research on the usage of hyperpolarized 13C MRI in monitoring metabolic changes in aging-related studies.

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