Baseline Correction of 1H MRS for Cerebral Glucose Quantification via Detecting H1-α-Glucose Peak at 7 T
Hideto Kuribayashi1, Yuta Urushibata1, Thuy Ha Duy Dinh2, Hirohiko Imai3, Sinyeob Ahn4, Ravi Teja Seethamraju5, Tadashi Isa2, and Tomohisa Okada2
1Siemens Healthcare K.K., Tokyo, Japan, 2Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Kyoto University Graduate School of Informatics, Kyoto, Japan, 4Siemens Medical Solutions, Berkeley, CA, United States, 5Siemens Medical Solutions, Boston, MA, United States
Glucose concentrations at posterior cingulate cortex in 20 young healthy subjects were quantitated via detecting H1-α-glucose peak at 5.23 ppm in 1H MRS at 7T. The spectra were analyzed using LCModel with data excluding a range of the residual water peak using PPMGAP parameter, which simply corrected baselines around the H1-α-glucose peak distorted from the tail of the residual water peak. The mean glucose concentration was estimated to be 1.0 mM via both sequences. Cramer-Rao lower bounds of fitting H1-α-glucose peak were significantly smaller in the semi-LASER (mean: 33.1 %) than those in the short-TE STEAM (49.8 %).
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