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Abstract #4364

Echo time optimization for in-vivo measurement of unsaturated lipid protons using J-difference-edited MRS.

Dingyi Lin1, Yi-Cheng Hsu2, Hong Li3, Jiaqiang Zhou3, Fenping Zheng3, and Min Wang1
1College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens healthineers ltd., Shanghai, China, 3Department of Endocrine, Sir Run Run Shaw Hospital, Hangzhou, China


In this study, J-difference editing was applied to unsaturated lipid protons. Density-matrix simulations were devised to demonstrate the TE-dependent signal evolution of J-coupled protons. Phantom and in-vivo experiments on human muscles were performed to verify the simulation results. The optimal TE was determined as 45 ms with the signals gain of 148.03% for allylic and 2.37% for diallylic groups on phantom and 160.16% for allylic and 13.22% for diallylic groups on human muscles, when compared to TE of 70 ms. This edited-MRS protocol allows robust quantification of unsaturated lipid composition in-vivo and investigation on lipid metabolism in future.

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