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Abstract #4375

T2 relaxometry based CSF fraction (CSFF) mapping is a better biomarker for brain drainage pathology than DTI-based free water (DTI-FW) mapping

Liangdong Zhou1, Thanh Nguyen2, and Yi Li2
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Weill Cornell Medicine, New York, NY, United States


We compared two free water methods, T2 relaxometry-based CSFF and DTI-based DTI-FW, by associating them with age, cognitive score RAVLT, amyloid beta deposition from PiB SUVr, tau deposition from MK6240, aqueduct CSF flow from PC-MRI and ventricle CSF clearance from MK-PET. Results show that CSFF outperforms DTI-FW in most relation pairs. CSFF works great for quantifying clearance related measures but DTI-FW failed.

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