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Abstract #4376

Flow Quantification for Cerebrospinal Fluid by Spatial-temporal Perturbation Patterns in SSFP

Yicun Wang1, Peter van Gelderen1, Jacco A. de Zwart1, Pinar S. Özbay1, Hendrik Mandelkow1, Dante Picchioni1, and Jeff H. Duyn1
1AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States


We report a fast quantitative CSF flow imaging method based on the spatial-temporal perturbation patterns formed at the transition bands in balanced steady-state-free-precession (SSFP) images when combined with a background magnetic field gradient. By modeling CSF flow as a combination of a pulsatile (AC) and a constant (DC) flow component across the cardiac cycle, a dictionary was generated based on Bloch simulations and used to translate the observed patterns to flow velocities. Monte-Carlo simulations were performed to evaluate the accuracy of the approach. CSF flow resulting from different physiological mechanisms was quantified in selected regions in 12 healthy subjects.

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