The altered CNS fluid flow dynamics and homeostasis mechanisms in response to blockade of lymphatic drainage to deep cervical lymph nodes (dcLN) is poorly understood. We used multi-modality MRI and computational fluid dynamics approach to study the same in rats with electrocauterized afferent lymphatic vessels of dcLN. The brain morphometry of Cauterized-dcLN rats showed localized volume expansion in Pons, Hippocampus and Corpus-callosum, while glymphatic speed maps showed hyperdynamic CSF flow in ambient and quadrigeminal cisterns. These results clearly show that the blockade of CSF drainage to dcLN alters CNS fluid homeostasis/flow dynamics, long-term may result in waste accumulation and neurodegeneration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords