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Abstract #4378

Cerebral Blood Flow Autoregulation is a Major Contributor to Flow Dynamics of Cerebrospinal Fluid

Yicun Wang1, Peter van Gelderen1, Jacco A. de Zwart1, Pinar S. Özbay1, Hendrik Mandelkow1, Dante Picchioni1, and Jeff H. Duyn1
1AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States


In addition to the well-established origin in cardiac and respiratory cycles, CSF pulsations may also result from the much slower variations in vascular tone associated with cerebral blood flow (CBF) autoregulation. Using a novel quantitative MRI approach, we measured CSF flow velocities and displaced volumes resulting from these three mechanisms in 12 healthy human controls. We found the autoregulatory effects to be a major factor, with associated CSF velocities comparable to and displaced volumes an order of magnitude larger than the cardio-respiratory effects. This may be an important mechanism underlying the CSF oscillations recently observed in resting-state fMRI.

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