Abstract #4379

Evaluation of Cerebral Blood Flow and BBB Water Exchange in an Aged African American Cohort

Brandon Ojogho¹, Farzan Abdolahi², Xingfeng Shao¹, Samantha Ma³, Chenyang Zhao¹, Kay Jann¹, Xuejuan Jiang², and Danny JJ Wang¹

¹Laboratory of FMRI Technology (LOFT) Mark & Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California (USC), Los Angeles, CA, United States, ²Department of Ophthalmology and Department of Preventive Medicine Keck School of Medicine University of Southern California (USC), Los Angeles, CA, United States, ³Siemens Healthcare, Los Angeles, CA, United States

Synopsis

This study evaluated CBF and BBB water exchange rate (kw) measured by diffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) in a cohort of aged African American individuals. The results showed decreasing CBF and kw with age, and higher CBF in females. Both CBF and kw were correlated with picture sequence memory test score. CBF was negatively correlated with white matter hyperintensities (WMH), free water (FW) and peak skeletonized mean diffusivity (PSMD), although age accounted for these correlations. These findings suggest the potential for CBF and kw as biomarkers of cerebral small vessel disease.

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