Abstract #4401

ACID - an open-source, bids compatible software for brain and spinal cord dMRI: preprocessing, DTI/DKI, biophysical modelling

Björn Fricke¹, Gergely David^1,2, Jan Malte Oeschger¹, Patrick Freund², Lars Ruthotto³, Karsten Tabelow⁴, and Siawoosh Mohammadi^1,5

¹Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Balgrist University Hospital, University of Zurich, Zürich, Switzerland, ³Department of Mathematics, Emory University, Atlanta, GA, United States, ⁴Weierstrass Institute for Applied Analysis and Stochastics, Berlin, Germany, ⁵Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

The ACID-Toolbox is an open-source toolbox for brain and spinal-cord diffusion data. It enables the preprocessing and creation of DTI/DKI, and biophysical parameter-maps in one single pipeline. Preprocessing covers correction for eddy-currents and motion-artefacts, susceptibility distortions and adaptive denoising. For model-fitting, the toolbox offers several algorithms to estimate the diffusion or the kurtosis tensors as well as estimation of biophysical parameters. ACID is integrated into the batch system of the Statistical-Parametric-Mapping (SPM12) software for the analysis of neuroimaging data and thus benefits from associated spatial and statistical processing modules. Additionally, ACID is BIDS compatible but also applicable to non-BIDS-conform data.

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