Optimization of Arterial Input Function Selection for Quantitative Head and Neck Dynamic Contrast-Enhanced (DCE) MRI
John A Roberts1, Seong-Eun Kim1, Evgueni Kholmovski1,2, Ying Hitchcock3, Tyler John Richards1, and Yoshimi Anzai1
1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Biomedical Engineering, University of Maryland, Baltimore, MD, United States, 3Radiation Oncology, Huntsman Cancer Institute, Salt Lake City, UT, United States
Arterial input functions measured in T1 weighted low tip angle SPGRE DCE MRI acquisitions may violate an important assumption used when modeling the conversion of image values to quantitative results: that all tissues of interest have reached steady state within the imaging volume. For arterial flow along the short axis of the imaging volume, blood may not dwell within the imaging volume long enough to reach steady state. We study both the location from which AIF will be measured and the acquisition parameters employed in order to optimize the accuracy of the DCE derived quantitative results.
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