Arterial input functions measured in T1 weighted low tip angle SPGRE DCE MRI acquisitions may violate an important assumption used when modeling the conversion of image values to quantitative results: that all tissues of interest have reached steady state within the imaging volume. For arterial flow along the short axis of the imaging volume, blood may not dwell within the imaging volume long enough to reach steady state. We study both the location from which AIF will be measured and the acquisition parameters employed in order to optimize the accuracy of the DCE derived quantitative results.
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