Histology is critical for validating pathology detected in ultra-high-resolution ex-vivo MRI. However, registering histological images with MR is challenging due to 3D deformations between MR and histology, 2D deformations during sectioning, and the fact that histological staining often occurs only in selected slices. Addressing these issues will enable quantification of complex histological features and their relationship with MRI, facilitating the discovery of novel in vivo imaging-based biomarkers of disease. Here, we demonstrate the use of a novel pipeline utilizing ultra-high-resolution specimen MRI, blockface imaging, and a modified tape transfer system for correlative MRI-paraffin-embedded histology of human brain tissue specimens.
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