Simultaneous parametric mapping techniques like 3D-QALAS offer means for reliable measurement of T1, T2, and proton density while also offering the generation of standard imaging contrasts. 3D-QALAS has also been shown to provide consistent brain tissue segmentation and volumetric analysis. However, high-resolution 3D-QALAS scans suffer from long scan times. Applying acceleration techniques like compressed SENSE, which are highly effective at reducing 3D scan times, can bring 3D-QALAS scan times under 3-minutes. Here we evaluate the acceleration of 3D-QALAS using multiple compressed SENSE factors on scan times, image quality, multiparametric mapping, and volumetric analysis.