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Abstract #4410

Quantitative multiple boli arterial spin labelling

Samantha Paterson1,2, Antoine Vallatos3, Camille Graff4, and William Matthew Holmes2
1EPIC, University of Leeds, Leeds, United Kingdom, 2GEMRIC, University of Glasgow, Glasgow, United Kingdom, 3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 4INP Grenoble - Phelma, Grenoble, France


The mbASL sequence is a hybrid between PASL and pCASL. It was shown to produce high SNR perfusion data. Quantification is crucial in order to produce accurate mbASL CBF maps. We have shown successful quantification by modifying the Buxton ASL kinetic model, optimising the number of pulses used for inversion and examining the optimal labelling slab thickness needed to maximise the SNR. We found CBF values that agree with current literature for mice and rats.

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