Improved Harmonization of Renal T2 Mapping Between Vendors using Stimulated Echo Compensation
Hao Li1, Charlotte E Buchanan2, David M Morris3, Alexander J Daniel2, João Sousa4, Steven Sourbron4, David L Thomas5,6,7, Susan T Francis2, and Andrew Nicholas Priest1,8
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 4Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 5Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 6Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 7Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 8Department of Radiology, Addenbrooke’s Hospital, Cambridge, United Kingdom
B1 inhomogeneity and non-ideal slice profiles introduce contributions from stimulated and indirect echoes into the multi-echo spin-echo (MESE) T2 mapping sequence, leading to variations in quantitative T2 values across scanners and vendors despite the use of a harmonised scan protocol. This study used an EPG-based fitting method to include corrections for stimulated-echo effects, applied to phantom and ‘travelling kidney’ data collected on scanners from three different MR vendors (GE, Philips, Siemens). Compared with conventional monoexponential fitting, EPG-based fitting substantially reduced the inter-scanner variations of T2 measurements. This improves the harmonization of the MESE T2 mapping sequence across MR scanner vendors.
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