Fast Multi-slice Quasi-steady-state (QUASS) APT MRI: Preliminary Results from Brain Tumor Patients at 3 Tesla
Hahnsung Kim1,2, Lisa C. Krishnamurthy 3,4, Kimberly B Hoang5, Ranliang Hu2, and Phillip Zhe Sun1,2
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Center for Visual and Neurocognitive Rehabilitation, Atlanta VA, Decatur, GA, United States, 4Department of Physics & Astronomy, Georgia State University, atlanta, GA, United States, 5Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States
The multi-slice CEST signal evolution was described by the spin-lock relaxation during saturation duration (Ts) and longitudinal relaxation during the relaxation delay time (Td) and post-label delay (PLD), from which the QUASS CEST was generalized to fast multi-slice acquisition. In addition, normal human subjects and tumor patients scans were performed to compare the conventional apparent and QUASS CEST measurements with different Ts, Td, and PLD. Bland-Altman analysis bias of the proposed QUASS CEST effects was much smaller than the PLD-corrected apparent CEST effects (0.03% vs. -0.54%), indicating the proposed fast multi-slice CEST imaging is robust and accurate.
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