The multi-slice CEST signal evolution was described by the spin-lock relaxation during saturation duration (Ts) and longitudinal relaxation during the relaxation delay time (Td) and post-label delay (PLD), from which the QUASS CEST was generalized to fast multi-slice acquisition. In addition, normal human subjects and tumor patients scans were performed to compare the conventional apparent and QUASS CEST measurements with different Ts, Td, and PLD. Bland-Altman analysis bias of the proposed QUASS CEST effects was much smaller than the PLD-corrected apparent CEST effects (0.03% vs. -0.54%), indicating the proposed fast multi-slice CEST imaging is robust and accurate.
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