Abstract #4419

Fast Multi-slice Quasi-steady-state (QUASS) APT MRI: Preliminary Results from Brain Tumor Patients at 3 Tesla

Hahnsung Kim^1,2, Lisa C. Krishnamurthy ^3,4, Kimberly B Hoang⁵, Ranliang Hu², and Phillip Zhe Sun^1,2

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ³Center for Visual and Neurocognitive Rehabilitation, Atlanta VA, Decatur, GA, United States, ⁴Department of Physics & Astronomy, Georgia State University, atlanta, GA, United States, ⁵Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States

Synopsis

The multi-slice CEST signal evolution was described by the spin-lock relaxation during saturation duration (T_s) and longitudinal relaxation during the relaxation delay time (T_d) and post-label delay (PLD), from which the QUASS CEST was generalized to fast multi-slice acquisition. In addition, normal human subjects and tumor patients scans were performed to compare the conventional apparent and QUASS CEST measurements with different T_s, T_d, and PLD. Bland-Altman analysis bias of the proposed QUASS CEST effects was much smaller than the PLD-corrected apparent CEST effects (0.03% vs. -0.54%), indicating the proposed fast multi-slice CEST imaging is robust and accurate.

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