The goal of this study was to investigate relationship between hemodynamic responses and underlying neurochemistry targeting cannabinoid receptor 1 (CB1R) in response to the injection of rimonabant in non-human primates using simultaneous positron emission tomography (PET) and function magnetic resonance imaging (fMRI). Following the rimonabant injection, fast and slow hemodynamic responses were identified throughout the brain. The CB1R occupancy estimates suggested that the radiotracer binding to CB1R was blocked by rimonabant highly in cerebellum and several brain regions. Future PET/fMRI studies with other CB1R-agonists/antagonists and more accurate occupancy estimates will provide further understanding about neurovascular coupling to CB1R.
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