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Abstract #4421

Spin-lock dispersion imaging detects changes in the intrinsic susceptibility microstructure of brain induced by oxygen

zhongliang zu1, Fatemeh Adelnia1, Kevin D Harkins1, Feng Wang1, and John C Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States


Previous research has shown that spin-lock imaging with low locking amplitude can quantify the spatial characteristics of intrinsic susceptibility gradients in tissues which likely reflect vascular microstructure. We evaluated the capability of spin-lock dispersion imaging with weak locking fields to detect vasoconstriction in rat brains under oxygen challenges.

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