Meeting Banner
Abstract #4425

In-tissue nano-assembly of Zn2+-responsive agent provides prolonged imaging time-window for longitudinal in vivo MRI studies

Deva Nishanth Tirukoti1, Liat Avram-Biton2, and Amnon Bar-Shir1
1Molecular Chemistry and Material Science, Weizmann Institute of Science, Rehovot, Israel, 2Chemical Research Support, Weizmann institute of Science, Rehovot, Israel


The fast clearance of small molecular probes limits their applicability as responsive agent and prevents their use in longitudinal study. We show here the design and implementation of a tripod-type responsive agent for Zn2+ mapping that assembled to 100nm nanostructure at physiological temperature. The designed fluorinated probe showed capabilities to monitor Zn2+ when combining CEST MRI and 19F-MRI. Upon its intracranial injection the synthetic probe assembled to large entities in the tissue that prevent its clearance from the injection site. This property allows to map its 19F-signal for more than 20 hours and will enable longitudinal studies in the future.

This abstract and the presentation materials are available to members only; a login is required.

Join Here