Restored Torsion and Longitudinal Strain in ACE Inhibitor Treated Hypertension
Alexander Wilson1,2, Gregory B Sands3, Vicky Y Wang2, Beau Pontre4, Daniel B Ennis1,2, Alistair A Young5, Ian J LeGrice3, and Martyn P Nash3,6
1Stanford Cardiovascular Institute, Stanford University, Stanford, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, 4Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand, 5Department of Biomedical Engineering, King's College London, London, United Kingdom, 6Department of Engineering Science, University of Auckland, Auckland, New Zealand
Tagged CMR was used to measure torsion and longitudinal strain in a rodent model of hypertensive heart disease. Long-term ACE inhibitor treatment restored ejection fraction, torsion and longitudinal strain by 24 months of age. Longitudinal strain was the first functional measure to be restored, and this may indicate that longitudinal strain is a sensitive imaging biomarker for assessing the efficacy of treatment with regards to reverse remodeling in hypertension.
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