Abstract #4441

Restored Torsion and Longitudinal Strain in ACE Inhibitor Treated Hypertension

Alexander Wilson^1,2, Gregory B Sands³, Vicky Y Wang², Beau Pontre⁴, Daniel B Ennis^1,2, Alistair A Young⁵, Ian J LeGrice³, and Martyn P Nash^3,6

¹Stanford Cardiovascular Institute, Stanford University, Stanford, CA, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States, ³Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ⁴Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand, ⁵Department of Biomedical Engineering, King's College London, London, United Kingdom, ⁶Department of Engineering Science, University of Auckland, Auckland, New Zealand

Synopsis

Tagged CMR was used to measure torsion and longitudinal strain in a rodent model of hypertensive heart disease. Long-term ACE inhibitor treatment restored ejection fraction, torsion and longitudinal strain by 24 months of age. Longitudinal strain was the first functional measure to be restored, and this may indicate that longitudinal strain is a sensitive imaging biomarker for assessing the efficacy of treatment with regards to reverse remodeling in hypertension.

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