Abstract #4442

Early Detection of Radiation-Induced Cardiotoxicity Using Hyperpolarized Pyruvate

Junjie Ma¹, Jun Chen¹, Elizabeth Zhang-Velten², Jayesh Sharma², Xuliang Wang³, Gabriele Schiattarella³, Thomas Gillette³, Joseph Hill^3,4, Craig R. Malloy^1,3,5, Vlad G. Zaha^1,3, Jae Mo Park^1,5,6, and Prasanna Alluri²

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, ³Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁶Electrical and Computer Engineering, UT Dallas, Richardson, TX, United States

Synopsis

Radiation-induced heart disease is a major source of morbidity and mortality in patients receiving thoracic radiation. In this study, radiation-induced changes in cardiac metabolism is investigated using hyperpolarized [1-¹³C]pyruvate MRI in animals and patients. Myocardial bicarbonate-to-lactate ratios decreased following radiation treatments while no change was observed in the global strain, suggesting radiation-induced mitochondrial dysfunction in the heart. This translational study demonstrates clinical potential of hyperpolarized ¹³C pyruvate for early and noninvasive detection of radiation-induced cardiac injury.

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