Abstract #4442
Early Detection of Radiation-Induced Cardiotoxicity Using Hyperpolarized Pyruvate
Junjie Ma1, Jun Chen1, Elizabeth Zhang-Velten2, Jayesh Sharma2, Xuliang Wang3, Gabriele Schiattarella3, Thomas Gillette3, Joseph Hill3,4, Craig R. Malloy1,3,5, Vlad G. Zaha1,3, Jae Mo Park1,5,6, and Prasanna Alluri2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4Molecular Biology, UT Southwestern Medical Center, Dallas, TX, United States, 5Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 6Electrical and Computer Engineering, UT Dallas, Richardson, TX, United States
Synopsis
Radiation-induced heart disease is a major source of morbidity and mortality in patients receiving thoracic radiation. In this study, radiation-induced changes in cardiac metabolism is investigated using hyperpolarized [1-13C]pyruvate MRI in animals and patients. Myocardial bicarbonate-to-lactate ratios decreased following radiation treatments while no change was observed in the global strain, suggesting radiation-induced mitochondrial dysfunction in the heart. This translational study demonstrates clinical potential of hyperpolarized 13C pyruvate for early and noninvasive detection of radiation-induced cardiac injury.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
