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Abstract #4460

R1rho Dispersion in Spinal Cord and Nerve

Alan E. Rivera-Garcia1, Juan Uribe2, Jay D. Turner2, John C. Gore3, and Ping Wang1
1Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States, 3Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States


Previous studies have demonstrated that at high fields (3T and beyond), dispersion of R1rho with different locking fields may reflect chemical exchange processes in biological tissues. This study aimed to investigate if R1rho dispersion is measurable in the spinal cord and nerve bundles. The results show that the dispersion is significant and measurable in both tissues, suggesting that R1rho dispersion has potential to characterize changes in composition or other physicochemical properties in nerve injuries and/or neurological disorders.

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