Light chain (AL) cardiac amyloidosis is a disease where abnormal proteins are deposited in multiple organs and is associated with elevated tissue stiffness. In cases with poor prognosis, autologous hematopoietic stem cell transplantation (ASCT) is used for therapy. Organ response monitoring is currently limited and challenging. The objective of this study was to evaluate the feasibility of using magnetic resonance elastography (MRE) to monitor stiffness changes in multiple organs pre- and post- ASCT therapy. At 3 months post therapy, significant reduction in MRE stiffness (p<0.001) was observed in organs that exhibited successful therapy response (defined by 9 month clinical outcomes).