High-resolution, high-contrast MRI protocol with extended delayed imaging for peritoneal mesothelioma
Milica Medved1, Hunter D. D Witmer2, Ankit D. D Dhiman2, Yaniv Berger3, Scott K Sherman4, Enal S Hindi2, Samuel G Armato III1, Ingrid S Reiser1, Aytekin Oto1, Roger M Engelmann1, Hedy L Kindler5, Nisa C Oren1, Carla B Harmath1, and Kiran K Turaga2
1Department of Radiology, The University of Chicago, Chicago, IL, United States, 2Department of Surgery, The University of Chicago, Chicago, IL, United States, 3Department of Surgery B, Chaim Sheba Medical Center, Ramat Gan, Israel, 4Department of Surgery, University of Iowa, Iowa City, IA, United States, 5Department of Medicine, The University of Chicago, Chicago, IL, United States
Improved methods for visualizing malignant peritoneal mesothelioma are needed. A high-resolution, high-contrast MRI protocol at 3T, including multiple delayed phases, was tested in 18 patients scheduled for laparoscopy/laparotomy. Both contrast washout and ongoing uptake was observed in individual lesions, pointing to a need for imaging with both short and long post-contrast delay times for optimal sensitivity. The per-patient average uptake/washout rate was significantly correlated with the cumulative nuclear score on pathology. The tested MRI protocol is feasible and may allow for more accurate visualization of peritoneal lesions and better guidance of management options.
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