Abstract #4479

High-resolution, high-contrast MRI protocol with extended delayed imaging for peritoneal mesothelioma

Milica Medved¹, Hunter D. D Witmer², Ankit D. D Dhiman², Yaniv Berger³, Scott K Sherman⁴, Enal S Hindi², Samuel G Armato III¹, Ingrid S Reiser¹, Aytekin Oto¹, Roger M Engelmann¹, Hedy L Kindler⁵, Nisa C Oren¹, Carla B Harmath¹, and Kiran K Turaga²

¹Department of Radiology, The University of Chicago, Chicago, IL, United States, ²Department of Surgery, The University of Chicago, Chicago, IL, United States, ³Department of Surgery B, Chaim Sheba Medical Center, Ramat Gan, Israel, ⁴Department of Surgery, University of Iowa, Iowa City, IA, United States, ⁵Department of Medicine, The University of Chicago, Chicago, IL, United States

Synopsis

Improved methods for visualizing malignant peritoneal mesothelioma are needed. A high-resolution, high-contrast MRI protocol at 3T, including multiple delayed phases, was tested in 18 patients scheduled for laparoscopy/laparotomy. Both contrast washout and ongoing uptake was observed in individual lesions, pointing to a need for imaging with both short and long post-contrast delay times for optimal sensitivity. The per-patient average uptake/washout rate was significantly correlated with the cumulative nuclear score on pathology. The tested MRI protocol is feasible and may allow for more accurate visualization of peritoneal lesions and better guidance of management options.

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