Abstract #4481

Intracellular Iron Chelation affects Cellular Metabolism in Triple Negative Breast Cancer Cells: Comparison between Human and Murine Models

Paola Porcari¹, Ellen Ackerstaff¹, Soe Su Min¹, Dov P. Winkleman¹, H. Carl Lekaye¹, and Jason A. Koutcher^2,3,4,5

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ²Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁴Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁵Weill Cornell Medical College, Cornell University, New York, NY, United States

Synopsis

We investigated the effect of Deferiprone, an iron chelator clinically used for non-cancer related diseases, on cellular metabolism and the impairment of cell growth in the human MDA-MB-231 and murine 4T1 triple-negative breast cancer models. By comparing the findings obtained on both cell lines through¹³C MRS monitoring with those related to mitochondrial respiration, we aimed to better understand the metabolic mechanism driving the changes that follow Deferiprone exposure. A stronger effect of DFP exposure was observed in human MDA-MB-231 cells than murine 4T1 cells.

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