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Abstract #4481

Intracellular Iron Chelation affects Cellular Metabolism in Triple Negative Breast Cancer Cells: Comparison between Human and Murine Models

Paola Porcari1, Ellen Ackerstaff1, Soe Su Min1, Dov P. Winkleman1, H. Carl Lekaye1, and Jason A. Koutcher2,3,4,5
1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 2Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 4Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 5Weill Cornell Medical College, Cornell University, New York, NY, United States

Synopsis

We investigated the effect of Deferiprone, an iron chelator clinically used for non-cancer related diseases, on cellular metabolism and the impairment of cell growth in the human MDA-MB-231 and murine 4T1 triple-negative breast cancer models. By comparing the findings obtained on both cell lines through 13C MRS monitoring with those related to mitochondrial respiration, we aimed to better understand the metabolic mechanism driving the changes that follow Deferiprone exposure. A stronger effect of DFP exposure was observed in human MDA-MB-231 cells than murine 4T1 cells.

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