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Abstract #4482

MR imaging of increased fibrotic tissue and hyaluronan deposition in the advanced stages of pancreatic ductal adenocarcinoma

Ravneet Vohra1, Yak-Nam Wang2, Helena Son3, Stephanie Totten2, Akshit Arora4, Adam Maxwell5, and Donghoon Lee1
1Radiology, University of Washington, Seattle, WA, United States, 2Applied Physics Laboratory, University of Washington, Seattle, WA, United States, 3Gastroenterology, University of Washington, Seattle, WA, United States, 4Arts and Sciences, University of Washington, Seattle, WA, United States, 5Urology, University of Washington, Seattle, WA, United States

Synopsis

Pancreatic cancer is expected to become the second leading cause of the cancer-related deaths in the USA by 2030. A genetically engineered mouse model (KPC) offers an alternative to transplantation models for preclinical therapeutic evaluation as it expresses mutations similar to human pancreatic cells. MRI can be used to monitor the tumor microenvironment in a variety of tumors. The goal of this study was to monitor fibrotic tissue and hyaluronan deposition in the KPC mouse model during the late stages of tumor development.

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