Abstract #4482

MR imaging of increased fibrotic tissue and hyaluronan deposition in the advanced stages of pancreatic ductal adenocarcinoma

Ravneet Vohra¹, Yak-Nam Wang², Helena Son³, Stephanie Totten², Akshit Arora⁴, Adam Maxwell⁵, and Donghoon Lee¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Applied Physics Laboratory, University of Washington, Seattle, WA, United States, ³Gastroenterology, University of Washington, Seattle, WA, United States, ⁴Arts and Sciences, University of Washington, Seattle, WA, United States, ⁵Urology, University of Washington, Seattle, WA, United States

Synopsis

Pancreatic cancer is expected to become the second leading cause of the cancer-related deaths in the USA by 2030. A genetically engineered mouse model (KPC) offers an alternative to transplantation models for preclinical therapeutic evaluation as it expresses mutations similar to human pancreatic cells. MRI can be used to monitor the tumor microenvironment in a variety of tumors. The goal of this study was to monitor fibrotic tissue and hyaluronan deposition in the KPC mouse model during the late stages of tumor development.

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