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Abstract #4484

A simulation study of the negative impact of fat on the accuracy of T1 measurements

Zhitao Li1, Shreyas S Vasanawala1, and Li Feng2
1Department of Radiology, Stanford University, Palo Alto, CA, United States, 2Biomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States


A simulation study examining the effects of fat in the accurate assessment of T1. The study looks at both the variable flip angle and Look-Locker methods, and different fat fractions and different T1 values are used in the simulation. The results indicated that while both VFA and Look-Locker methods’ accuracy are affected by fat, VFA method’s biases increases more rapidly as fat fraction goes up, and the bias for larger spin species with larger T1s are more severely impacted by the presence of fat.

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