Abstract #4485

Comparison of analytical BOLD-fMRI models against Two-Photon Microscopy and Monte Carlo simulations

Jordan Charest¹, Pierre-Olivier Schwarz¹, Mathieu Walsh¹, Élie Genois², Louis Gagnon³, and Michèle Desjardins¹

¹Physics, Engineering Physics and Optics, Laval University, Quebec City, QC, Canada, ²Physics, University of Sherbrooke, Sherbrooke, QC, Canada, ³Radiology and Nuclear Medicine, Laval University, Quebec City, QC, Canada

Synopsis

BOLD fMRI arises from a complex physiological and physical cascade of events taking place at the level of the cortical microvasculature which constitutes a medium with complex geometry. Several analytical models of the BOLD contrast have been developed but these have not been compared directly against detailed bottom-up modeling methods. Using a recent 3D modeling method based on Two-Photon Microscopy and Monte Carlo simulations, we tested the accuracy of two analytical models to predict the amplitude of the BOLD response at 1.5T, 3T, 4.7T and 7T for both gradient echo and spin echo acquisition protocols.

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