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Abstract #4485

Comparison of analytical BOLD-fMRI models against Two-Photon Microscopy and Monte Carlo simulations

Jordan Charest1, Pierre-Olivier Schwarz1, Mathieu Walsh1, Élie Genois2, Louis Gagnon3, and Michèle Desjardins1
1Physics, Engineering Physics and Optics, Laval University, Quebec City, QC, Canada, 2Physics, University of Sherbrooke, Sherbrooke, QC, Canada, 3Radiology and Nuclear Medicine, Laval University, Quebec City, QC, Canada


BOLD fMRI arises from a complex physiological and physical cascade of events taking place at the level of the cortical microvasculature which constitutes a medium with complex geometry. Several analytical models of the BOLD contrast have been developed but these have not been compared directly against detailed bottom-up modeling methods. Using a recent 3D modeling method based on Two-Photon Microscopy and Monte Carlo simulations, we tested the accuracy of two analytical models to predict the amplitude of the BOLD response at 1.5T, 3T, 4.7T and 7T for both gradient echo and spin echo acquisition protocols.

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